Erik ten Hag's side are back in action when they make the trip to Selhurst Park on Bank Holiday Monday but they could be without some key figures for the match.
Bruno Fernandes was labelled a doubt after he suffered an unspecified issue after the Burnley draw, while Marcus Rashford is not expected to be back until later in the month. The likes of Luke Shaw, Lisandro Martinez and Raphael Varane all remain longer term concerns, with options still very much limited in defence.
Here is a round-up of all the injury news and expected return dates ahead of the Palace clash.
1. Jonny Evans - 6 March vs Crystal Palace (A)
The Northern Irish defender returned to training earlier this week and is set to be named in the squad to face Crystal Palace. Photo: Manchester United via Getty Images
2. Bruno Fernandes - 6 March vs Crystal Palace (A)
Fernandes was labelled a doubt to be involved but it was only believed to be a minor issue relating to his recent broken hand. It would be a surprise if he finally missed a match through injury. Photo: Getty Images
3. Scott McTominay - 6 March vs Crystal Palace (A)
McTominay's knee scare against Burnley wasn't as bad as first feared and he is set to be named on the bench on Monday night. Photo: Manchester United via Getty Images
4. Marcus Rashford - 12 March vs Arsenal (H)
Rashford's recent issue still hasn't healed and he isn't expected to be back until the Arsenal game at the very earliest. Photo: AFP via Getty Images